Memodyne Official Website › Memory Supplement Guide
Memory Supplement GuideThe memory supplement guide: what the evidence shows, next to Memodyne
The largest trials in this category are null, and the best cognitive evidence is not in a bottle.
Ginkgo failed its biggest trial. A daily multivitamin produced small memory improvements in two large randomised trials. Hearing treatment, blood-pressure treatment and sleep all carry randomised cognitive results, and none of the three is sold as a supplement.
The large trials, the small ones, the three interventions nobody bottles, and where a six-ingredient capsule sits among them.
The large memory supplement trials, and what they found
| Trial | What it tested | What it found |
|---|---|---|
| GEM, JAMA 2008 | 120 mg of ginkgo biloba twice a day in 3,069 adults aged 75 and over, median follow-up 6.1 years | No reduction in all-cause dementia or Alzheimer's disease |
| COSMOS-Web, 2023 | A daily multivitamin in older adults, with memory as the outcome | A small improvement in memory |
| COSMOS-Mind, 2023 | Cocoa extract and a multivitamin, with cognitive function as the outcome | A cognitive benefit from the multivitamin arm |
| The Perth analysis, 2025 | 1,200 mg a day of calcium carbonate for five years in 1,460 women aged 70 and over, followed for 14.5 years | No change in dementia risk in either direction |
Four large randomised efforts. One clear null, two small positives from the least glamorous product in the aisle, and one safety reassurance.
The pattern is worth sitting with. The most heavily marketed botanical in the category failed its largest trial outright, and the product that produced a measurable memory result is the one sold in supermarkets for a few dollars a month.
The three cognitive interventions nobody sells in a bottle
Treating hearing loss
ACHIEVE randomised a hearing intervention against a health-education control in older adults with hearing loss, with cognitive decline as the outcome. It is a multicentre randomised trial in the Lancet, which is a considerably stronger form of evidence than anything behind any supplement in this aisle.
Treating blood pressure
SPRINT MIND compared intensive with standard blood-pressure control and looked at probable dementia. It is the kind of trial that supplement marketing borrows the language of and never produces.
Sleep
A 2026 review covers what memory consolidation during sleep actually is and how reliably it is observed. It costs nothing, it is difficult to do, and it is the most underrated item on this page.
None of the three is for sale here, which is exactly why they are printed here. A reader weighing a capsule deserves the comparison, and a shop that withheld it would be selling on an omission.
Why supplement doses and trial doses diverge
The single most useful calculation a buyer can make is the ratio between what a capsule holds and what the trial behind its headline ingredient used. Where a panel is published, it takes two minutes.
| Ingredient | Amount its trial used | What that means in a capsule |
|---|---|---|
| L-Citrulline | 8.8 g a day for five days | Eight point eight grams is roughly the weight of a large capsule's entire contents, several times over |
| L-Arginine AKG | 12 g a day, in three 4 g doses | A dose taken three times a day in a shaker, not once in a capsule |
| Citrulline malate | 3 g a day for six weeks | The lowest of the amino-acid doses here, and still grams |
| Calcium carbonate | 1,200 mg a day for five years | Plausible in a capsule on its own; less so alongside five other names |
| Niacin | Tens of milligrams; the upper intake level is 35 mg a day | The one name in this family whose studied amount fits comfortably |
The last row is the exception that proves the point: vitamins are measured in milligrams, amino acids in grams, and a capsule is a container of a fixed size.
That is not an argument against amino acids. It is an argument for reading the panel, and for treating a product that does not publish one as a product that has declined to be measured.
Where Memodyne sits in that picture
Memodyne in its favour
- It belongs to the nitric-oxide group, which has real vascular evidence behind it.
- It uses citrulline in two forms, which is the correct choice if raising plasma arginine is the aim.
- It contains no botanical with a large null trial behind it.
- It names nothing resembling an unapproved drug ingredient.
- It carries clearer refund terms than most of this category.
Memodyne against
- It publishes no amounts, so the most useful calculation on this page cannot be performed on it.
- Its sixth name differs between the bottle and the seller's own page.
- Four of its six names do the same job, which is fewer distinct mechanisms than the count suggests.
- The one cerebrovascular trial behind its lead ingredient was in young athletes at 8.8 g a day.
- The cheapest product in the aisle has better randomised memory evidence than anything on this label.
Memory supplement questions Memodyne readers ask
Do memory supplements work?
As a class, the evidence is thin and the largest trials are null. The exception is the plainest product in the aisle: a daily multivitamin, which produced small memory improvements in two large randomised trials in older adults.
What has the strongest evidence for cognition?
Not a supplement. Treating hearing loss and treating blood pressure both have randomised trials with cognitive outcomes, and sleep has a substantial literature.
Is ginkgo worth taking?
The largest trial of it randomised 3,069 adults over 75 to 120 mg twice a day and found no reduction in dementia. That is about as clear a null result as this category has produced.
Why do supplement trials use such large doses?
Because that is what it takes to move a measurement. The gap between a trial dose and a capsule dose is the single most useful thing a buyer can calculate, where the label makes it possible.
Who publishes this Memodyne website?
- DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA. 2008;300(19):2253-62. PMID 19017911. https://pubmed.ncbi.nlm.nih.gov/19017911/
- Yeung LK, Alschuler DM, Wall M, et al. Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial. Am J Clin Nutr. 2023;118(1):273-282. PMID 37244291. https://pubmed.ncbi.nlm.nih.gov/37244291/
- Baker LD, Manson JE, Rapp SR, et al. Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial. Alzheimers Dement. 2023;19(4):1308-1319. PMID 36102337. https://pubmed.ncbi.nlm.nih.gov/36102337/
- Ghasemifard N, Lewis JR, Radavelli-Bagatini S, et al. Calcium supplementation and the risk of dementia in the Perth Longitudinal Study of Aging Women: a post-hoc analysis of a randomised clinical trial for fracture prevention. Lancet Reg Health West Pac. 2025;63:101694. PMID 41346785. https://pubmed.ncbi.nlm.nih.gov/41346785/
- Lin FR, Pike JR, Albert MS, et al. Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial. Lancet. 2023;402(10404):786-797. PMID 37478886. https://pubmed.ncbi.nlm.nih.gov/37478886/
- SPRINT MIND Investigators for the SPRINT Research Group; Williamson JD, Pajewski NM, Auchus AP, et al. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA. 2019;321(6):553-561. PMID 30688979. https://pubmed.ncbi.nlm.nih.gov/30688979/
- Yasser E, Ayache L, El Khayat H, et al. Sleep and memory consolidation: Neural and cognitive perspectives. Prog Brain Res. 2026;299:137-176. PMID 42547206. https://pubmed.ncbi.nlm.nih.gov/42547206/
- Li A, Li H, Chen J. The effects of L-citrulline supplementation on cerebrovascular function during sprint interval training in taekwondo athletes. J Exerc Sci Fit. 2025;23(3):222-228. PMID 40474881. https://pubmed.ncbi.nlm.nih.gov/40474881/
- Campbell B, Roberts M, Kerksick C, et al. Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition. 2006;22(9):872-81. PMID 16928472. https://pubmed.ncbi.nlm.nih.gov/16928472/
- Ramos-Hernández R, Pascual-Fernández J, Álvarez-Pardo S, et al. Short-term citrulline malate supplementation enhances lower-limb function in physically active older women: A pilot randomized controlled trial. Clin Nutr ESPEN. 2026;74:103356. PMID 42162613. https://pubmed.ncbi.nlm.nih.gov/42162613/
- Minto C, Vecchio MG, Lamprecht M, Gregori D. Definition of a tolerable upper intake level of niacin: a systematic review and meta-analysis of the dose-dependent effects of nicotinamide and nicotinic acid supplementation. Nutr Rev. 2017;75(6):471-490. PMID 28541582. https://pubmed.ncbi.nlm.nih.gov/28541582/
- Cohen PA, Avula B, Khan I. The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements. Clin Toxicol (Phila). 2022;60(10):1156-1158. PMID 35959800. https://pubmed.ncbi.nlm.nih.gov/35959800/
- Memory. MedlinePlus, U.S. National Library of Medicine. https://medlineplus.gov/memory.html
- Using Dietary Supplements Wisely. National Center for Complementary and Integrative Health, National Institutes of Health. https://www.nccih.nih.gov/health/using-dietary-supplements-wisely
Order Memodyne with the category in view
The largest trials in this aisle are null and the best cognitive evidence is not in a bottle. A daily capsule is a small part of a picture, and it is worth buying as one.
Two bottles $158 · six bottles $294 · 60 days from purchase
Order Memodyne From This ShopLot MEM-26/ME-6233 · 30 capsules, one each morning · dispatched from within the United States
